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xPharm® |
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Dr. Uli Heigl of Symyx (MDL), describes this company’s xPharm
database as “a fully interactive database that covers
pharmacological information: sets of records, targets, agents,
information on disorders, principles that govern drug-target
interactions, and so on.” He adds, “All of the records are indexed
and interlinked. Any information is just a mouse click away.” In
addition, this database adds references to the data and hyperlinks
to full text of related journal articles. “This database can be used
to see what kinds of targets are linked to specific diseases, what
disorders are related to specific targets,” says Heigl.
from
Life Science Technologies: Combinatorial and
Computational Chemistry – Creating New Therapeutic Compounds by Mike
May and Gary Heebner, 17 March 2006 issue of
Science.
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interactive database covering molecular targets, agents, related
disorders, and the principles that govern their interactions. |
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Use xPharm to:
- Select appropriate targets for screening of new compounds
- Predict adverse effects
- Identify experts in selected areas of research
- Retrieve information for business plans and grants
- Prepare lecture materials
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Unsurpassed
Pharmacology Content
xPharm's content has been organized and commissioned by an
outstanding editorial board led by Executive Editors, S.J. Enna and
David B. Bylund.
xPharm's individual records are contributed and reviewed by
recognized experts in pharmacology and life sciences. More than 500
contributors have been drawn from academia, government and the
corporate world, each contributor bringing his or her unique
expertise to you in one integrated database.
xPharm's content is rich in the numerical data used to define
pharmacological relationships. It is written in a concise,
citation-rich style that permits easy reading and assimilation of
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Get the answers
that you need
xPharm provides direct answers to specific questions such as:
- What targets are associated with control of blood pressure?
- Where and under what physiological conditions are Alpha-1A
Adrenoceptors expressed?
- What dose of a specific drug will have an effect in my animal
model?
- What are the mechanisms of action of existing antihypertensive
drugs?
- What kind of adverse effects are associated with monoamine
oxidase inhibitors?
All records in xPharm are indexed and interlinked so that you can
view any record by simply clicking on a hyperlink anywhere within
xPharm.
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xPharm contains detailed
integrated records on:
- Targets
- Disorders
- Principles
- Agents
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Detailed information
xPharm contains detailed information and corresponding links for
more than 400 pharmacological targets. |
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Simple or highly structured queries
xPharm enables both simple and highly structured queries. Results
can be specified so that only individual pieces of information from
each record are displayed. |
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Easy-to-use table of contents
An easy-to-use browsable table of contents allows researchers to
peruse the entire contents of xPharm to locate the information they
need. |
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What's New |
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Focused Compound Libraries, Wiesbaden Oct 10-12,
2006 |
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CIC , Goslar, Nov. 12-14, 2006 |
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ChemInfo 2006, Jerusalem, November 2006 |
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Publications: |
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xPharm: A Preclinical
Information Portal for Discovery Researchers in Institutions
of Higher Learning
Marie K. Saimbert
Journal of Electronic Resources in Medical
Libraries, Vol. 3(1) 2006
Available online at
http://www.haworthpress.com/web/JERML © 2006 by The
Haworth Press, Inc. All rights reserved.
doi:10.1300/J383v03n01_07 63
Some attributed researcher
quotes:
"It saved hours of time in
looking for primary research articles that are specific to
my research model"
"I was interested in
Coagulation Factor IX as a target for the development of
potential antithrombotic drugs. All I had to do was type in
Factor IX in xPharm's search box and all of the information
I desired, including physiological function in humans,
probes that have already been characterized, pharmacological
activators and antagonists, were cited from over 100 journal
articles. Prior to using xPharm, I tried a search on Ovid
MEDLINE. I had combined the search queries Factor IX and
Drug Delivery Systems, resulting in only seven articles."
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